Multiple Prescriptions, Multiple Pills, and Additional Cost1-6
ERA + PDE5i regimens may require 3 to 13 pills a day with 2 separate prescriptions2-4
$15-$150
Out-of-pocket cost range of a PDE5i7
Based on the potential range of medication costs before a patient’s deductible is met.
Compare OPSYNVI® (macitentan/ tadalafil) dosing regimen
to loose-dose combination therapy
ERA=endothelin receptor antagonist; PAH=pulmonary arterial hypertension; PDE5i=phosphodiesterase type 5 inhibitor.
References: 1. Humbert M, Kovacs G, Hoeper MM, et al; ESC/ERS Scientific Document Group. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS). Eur Heart J. 2022;43(38):3618-3731. 2. Pulido T, Adzerikho I, Channick RN, et al; SERAPHIN Investigators. Macitentan and morbidity and mortality in pulmonary arterial hypertension. N Engl J Med. 2013;369(9):809-818 and suppl 1-21. doi:10.1056/NEJMoal213917 3. ADCIRCA® Prescribing Information. Eli Lily & Co. 4. REVATIO® Prescribing Information. Pfizer. 5. Data on file. Managed Markets Insights and Technology, LLC™, a trademark of MMIT, as of January 2025. 6. Data on file. Johnson & Johnson and its affiliates. Master Price List. Accessed January 2, 2026. 7. Data on file. Johnson & Johnson and its affiliates. Potential OOP for PDE5i. May 7, 2025.