REDUCTION IN PVR

OPSYNVI® Provided Greater Reductions in PVR Compared With Macitentan and Tadalafil Alone1

Change in PVR at Week 16
(OPSYNVI® vs macitentan)1

OPSYNVI® clinical trial PVR results for OPSYNVI® versus MacitentanOPSYNVI® clinical trial PVR results for OPSYNVI® versus Macitentan

Change in PVR at Week 16
(OPSYNVI® vs tadalafil)1

OPSYNVI® clinical trial PVR results for OPSYNVI® versus TadalafilOPSYNVI® clinical trial PVR results for OPSYNVI® versus Tadalafil

Treatment with OPSYNVI® (macitentan/tadalafil) resulted in a statistically significant treatment effect in PVR vs macitentan monotherapy and tadalafil monotherapy1

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CL=confidence limits; PAH=pulmonary arterial hypertension; PVR=pulmonary vascular resistance.

Reference: 1. OPSYNVI® (macitentan/tadalafil) full Prescribing Information. Actelion Pharmaceuticals US, Inc.

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